Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity and iron export. APP is best known as the precursor molecule whose proteolysis generates beta ...
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http://en.wikipedia.org/wiki/Amyloid_precursor_protein
(from the article `Alzheimer disease`) ...dendritic, or amyloid plaques—consist of deteriorating neuronal material surrounding deposits of a sticky protein called beta-amyloid. This ...
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http://www.britannica.com/eb/a-z/a/66
<protein> Individuals with Alzheimer's disease are characterised by extensive accumulation of amyloid in the brain, referred to as senile plaques. These consist of a core of amyloid fibrils surrounded by dystrophic neurites. The principal component of the amyloid fibrils is B/A4, a peptide derived from the larger APP. The specific role of amy...
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http://www.encyclo.co.uk/local/20973
(APP) a large transmembrane glycoprotein expressed on the cell surface and of uncertain function; endocytosis and cleavage can produce abnormal 40 to 43 amino acid peptides which aggregate to form Aβ amyloid, associated with Alzheimer disease.
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http://www.encyclo.co.uk/local/21001
Individuals with Alzheimer's disease are characterized by extensive accumulation of amyloid in the brain, referred to as senile plaques. These consist of a core of amyloid fibrils surrounded by dystrophic neurites. The principal component of the amyloid fibrils is B/A4, a peptide derived from the larger APP. The specific role of amyloid protein is unclear but it is thought that amyloid deposits may cause neurons to degenerate. Amyloid deposits al …
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http://www.encyclo.co.uk/visitor-contributions.php
Type: Term Definitions: 1. a cell-surface receptor involved with neuritic growth, neuronal adhesion, and axonogenesis; cleavage of amyloid precursor protein by secretases generates beta-amyloid; abnormal synthesis of amyloid precursor protein leads to plaque formation in Alzheimer disease.
Found on
http://www.medilexicon.com/medicaldictionary.php?t=72942
No exact match found.
